Main Sequence surpasses $1 billion funds under management for deep tech as it launches new Fund

July 25, 2023

Reaching $1B under management in just six years, deep tech backers of Samsara, Regrow, and Q-CTRL tackle decarbonisation and critical technologies with latest $450M fund.

AUSTRALIA, 26 JULY 2023 — Main Sequence, the Australian deep tech investment fund founded by Australia’s national science agency CSIRO, has today announced the first close of its third fund, raising $AU450 million, surpassing the milestone of $AU1 billion in total funds under management.

Recognising that Australia’s expansive research and innovation capabilities offer a unique opportunity to solve global challenges, the fund welcomed the participation of large institutional funds, wealth groups and top tier climate investors. These include high profile new investors as well as many returning investors, underlining their confidence in the fund. Investors include Hostplus, LGT Crestone, Morgan Stanley Wealth Management, Temasek1, NGS Super, Australian Ethical Investment, Daiwa Securities Group and The Grantham Foundation.

The fund also includes the first half of the committed $AU150 million CSIRO investment announced as stage three of the federal government’s Australia’s Economic Accelerator program. It comes as Main Sequence backs and builds companies that reflect Australia’s national priorities investing in ideas that will diversify and transform Australia’s industry and economy. 

Investment stages and funds to date

Founded in 2017, the firm has backed 53 companies including Regrow, Advanced Navigation, and Q-CTRL. The Australian deep tech companies supported by Main Sequence have created over 2,100 new jobs, and the market value of those companies has grown to over $AU6.8 billion.

“We embark on an extraordinary journey with this fund, guided by two key imperatives. First, decarbonisation—we want to ensure more translation of climate research into the solutions urgently needed to address our environmental impact. Alongside this, we are advancing critical technologies central to Australia’s national interest including cybersecurity to protect citizens and infrastructure, quantum computing to unlock new possibilities, and advanced semiconductor technology to fuel innovation,” commented Mike Zimmerman, Partner at Main Sequence.

“Our focus remains on big, global challenges that need scientific backing, patient capital and long-term vision to solve. The community we have created around this mission cares deeply about finding and scaling solutions to planetary problems like decarbonisation, feeding a growing population and enabling the next intelligence leap. Thanks to their support, we have the flexibility and fortitude to back and build breakthrough companies grounded in research, and help them actualise their impact for decades to come.”

This is the third fund from Main Sequence, following its $AU240 million original fund and $AU330 million second fund which closed in 2018 and 2021 respectively. 


Main Sequence is not only seeking out these companies, it is finding novel research and building them from scratch through its unique ‘Venture Science’ model of investment. The approach pairs deep scientific knowledge with the industry expertise and capital funding required to build entire industries and ecosystems around solving a global-scale challenge.

Our last fund saw the launch of five Venture Science startups— Endua, Eden Brew, Quasar Sat, Cauldron, and Samsara Eco. We are keeping up this momentum with Fund 3, pioneering new frontiers in biotechnology and plan to continue co-founding new companies at the bleeding edge of exciting advances in food and fibres with Fund 3,” said Gabrielle Munzer, Partner at Main Sequence. 

Main Sequence's reach across Australia

“We are continuing to harness the forces of entrepreneurship and research to address the ‘Valley of Death’. We see incredible promise in pre-seed investments and our involvement with Australia’s Economic Accelerator, CSIRO’s ON Accelerator and University accelerator programs like UNSW Founders’ SynBio 10x program means we can deepen our focus on unearthing cutting-edge ideas.”


Daiwa Capital Markets Australia Limited, CEO, Susumu Handa: “We are very excited to be the first Japanese investor of this excellent venture capital fund. Through the collaboration with Main Sequence, we are confident to be a bridge between two countries’ startup ecosystems to leverage our bilateral relationships for creating shared values. We can’t wait to work with partners who have passions for global challenges like decarbonisation, food, healthcare, space, and more.”

Hostplus, Chief Investment Officer, Sam Sicilia: “Deep technology (deeptech) companies have the potential to deliver strong long-term returns on behalf of our members whilst aiming to provide solutions to societal, technological or ecological problems. Hostplus is pleased to continue our involvement with Main Sequence – a VC firm specialising in deeptech – with investment in their third fund.”

LGT Crestone, CEO, Michael Chisholm: “We’ve always had a clear vision: to bring world-class investment opportunities to Australian HNWI. The Main Sequence Fund is the latest example of us realising this vision.”

NGS Super, CIO, Ben Squires: “NGS Super has a focus on sustainable investing, which is why we are so excited about the collaboration with Main Sequence Fund who share the same ethos around addressing global challenges like decarbonisation.

About Main Sequence 

Main Sequence is tackling the world’s biggest challenges by turning today’s scientific discoveries into tomorrow’s industries. It works closely with scientists, researchers and industry collaborators to create, fund and accelerate new companies and industries across health, food, space, transport, security and deep tech to accelerate humanity for a more prosperous future.

Founded in Australia in 2017, by the Australian Government and the national science agency CSIRO, Main Sequence’s Fund I and Fund II have invested in 51 companies that are solving the sustainability of food production, plastic pollution crisis, and renewable energy transition, while shielding us from increasing cyber threats and more.

1Subject to satisfaction of customary regulatory approvals

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