Introducing Main Sequence

Unreasonable inventors are combining cutting edge scientific discoveries with the world's biggest challenges to build the next generation of global companies.

These are the companies we create and invest in at Main Sequence.

We have over $1b under management from lean-in LPs who help our portfolio to prosper.

We are investing in the difficult to build companies others struggle to support.

Our co-founder is Australia's $1.3b annual budget science agency - CSIRO

We invest from seed to Series B, starting our journey as early as possible, driving advantage into our portfolio.

Our Advantage

Deep tech inventors need more. We have custom built Main Sequence to be ready to help you solve some of the world's greatest challenges with science.

We are hands-on and have built a services offering to support founders alongside our capital.

Learn More

Our story

Main Sequence was founded by CSIRO in 2017 to address the ‘valley of death’ between research and commercialisation.

Main Sequence’s origins within CSIRO reflect its commitment to amplifying connections between industry, research and infrastructure to accelerate deep technology development, and reinvesting economic returns from commercialisation back into science.

CSIRO Innovation Funds 1 and 2 managed by Main Sequence, have invested in 51 companies since establishment in 2017. These companies have created over 2100 jobs by working with partners in industry, CSIRO, and 28 Australian universities.

The $240 million first CSIRO Innovation Fund, built on a cornerstone investment by government and CSIRO has completed its portfolio and invested in 27 companies since establishment in 2017.

The second $300 million CSIRO Innovation Fund commenced investing mid-2021 and has invested in 24 companies.

During 2023 Fund 3 has raised $450 million, surpassing $1 billion in total funds under management and making its first five Fund 3 investments.

Our Co-Investors

We collaborate with a global community of co-investors who work with us to help our companies scale.

Six Challenges

We love companies that solve one or more of these challenge areas.
Explore each one below and get to know some of the companies we have already backed.

Stay in Touch

Deep Tech Adventures is our monthly newsletter sharing the latest in what we are seeing & thinking about plus the latest news from our portfolio.

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