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About Main Sequence

What is Main Sequence?

Main Sequence is Australia's deep tech venture capital firm. We create and invest in companies built on science, backing founders who are rebuilding the systems the world depends on: energy, food, health, industry, space and intelligence.

Who founded Main Sequence?

Main Sequence was founded in 2017 by CSIRO, Australia's national science agency, with the Australian Government. It was set up to bridge the gap between research and commercialisation, so more Australian science becomes global companies.

What is Main Sequence's relationship with CSIRO?

CSIRO founded Main Sequence and is an investor in our funds. That connection gives our founders close access to Australian research, researchers and infrastructure.

Is Main Sequence funded by the government?

Partly. Our first fund was built on a cornerstone investment from the Australian Government and CSIRO. Fund 2 was raised entirely from private capital, and Fund 3 brings together institutional investors, superannuation funds and a CSIRO commitment.

How much does Main Sequence manage?

Main Sequence manages over A$1 billion across three funds: A$240 million in Fund 1, A$310 million in Fund 2 and A$450 million in Fund 3.

What does Main Sequence invest in?

We invest in deep tech companies working across six systems: energy, food, health, industry, space and intelligence. We look for hard technical problems where science creates a lasting advantage.

How do I keep up with Main Sequence?

Subscribe to Deep Tech Adventures, our monthly newsletter of portfolio news and what we're seeing in deep tech.

For founders

What stage does Main Sequence invest at?

Main Sequence invests from pre-seed through Seed, Series A and Series B. Pre-seed investments come through Atmosphere, our dedicated pre-seed fund.

Do I need a connection to Australian research?

Yes. Every Main Sequence company connects to Australian publicly funded research, such as a university or CSIRO. That link doesn't need to exist before we invest; we can design it in together.

What makes a company a fit?

A fit is a company going after a large problem in one of our six systems, using science or hard engineering its team is uniquely placed to deliver. We back founders early and stay through the hardest stretch of building.

How do I pitch Main Sequence?

Pitch us through the form on our Pitch page. Share your deck, the problem you're solving, your solution and your research connection.

What support do founders get beyond capital?

Our platform team works alongside founders on story, people and community, from first pitch to next round.

Atmosphere and Venture Science

What is Atmosphere?

Atmosphere is Main Sequence's dedicated pre-seed fund. It backs founders at the very start, often before there's a company. Atmosphere companies include Facet and Deteqt.

How is Atmosphere different from Main Sequence's main funds?

Atmosphere invests at pre-seed; our main funds invest from Seed to Series B. Atmosphere companies can go on to raise from the main funds, so founders can have one partner from first cheque to growth.

What is Venture Science?

Venture Science is how Main Sequence creates companies from the problem back. We start with a large market need, then bring together the science, founders, capital and customers to solve it. Companies built this way include Eden Brew, Endua, Quasar Satellite Technologies, Samsara Eco and v2food.

Can I join a Venture Science company as a founder?

Yes. We look for scientists, engineers and operators who want to found a company around a problem we're working on. Get in touch through our Contact page.

For investors

Can I invest in Main Sequence?

Our funds are open only to qualified wholesale investors with an investment horizon of more than 10 years. We're raising Fund 4, with a first close expected in early 2027. Register your interest on our Invest page.

I'm an existing investor. Where do I go?

Log in to the investor portal, or email operations@mseq.vc with questions about your account.

For researchers

I'm a researcher. How can Main Sequence help?

We help researchers test whether their work could become a company, then build and fund it with them. Start on our For Researchers page.