About Main Sequence
Built for deep tech.
Deep tech is the work of rebuilding the systems the world depends on. Main Sequence was founded out of CSIRO in 2017 to back the founders doing it.
80
Companies backed
300
Research links across 32 universities and CSIRO
3
Funds, $1B under management
Our co-investors
Deep tech takes partners.
Why deep tech
Where we invest
From lab to company
Firm advantage
Why deep tech
The hard work is the opportunity.
Rebuilding food, energy, compute, industry, health and space takes years of science, capital and patience. Few investors stay the course. The companies that make it become very hard to replace, and that is where most of the next decade's value will be created.
Where we invest
Six systems the world depends on.
Food. Energy and materials. Compute. Industry. Health. Space.
From lab to company
Proven science stalls in the lab. We get it out.
More than three in four Main Sequence companies are linked to Australian public research, from CSIRO and universities across the country. The science already works. We bring the capital, the company and the team to take it to market.
Firm advantage
Built to stay the course.
Venture Science builds companies around problems industry needs solved. Atmosphere backs founders at the very start. The Platform works alongside them from first pitch to next round.
Since 2017.
Main Sequence was founded by CSIRO in 2017 to bridge the valley of death for Australian research. We invest in spinouts, startups and SMEs connected to Australia's publicly funded R&D, and reinvest the returns back into science. The $240 million CSIRO Innovation Fund was built on a government and CSIRO cornerstone. Fund 2 followed with $310 million raised entirely from private capital. Together they backed 51 companies. Fund 3 raised $450 million and has been investing since 2023, taking funds under management past $1 billion. The government has committed $150 million through CSIRO to Funds 3 and 4.
Fund 1
$240M. CSIRO cornerstone.
Government and CSIRO cornerstone
Fund 2
$310M. All private.
51 companies across Funds 1 and 2
Fund 3
$450M. Fund 3.
Funds under management pass $1B
Today
$1B. Three funds.
80+ companies backed
Our team
Scientists.
Operators.
Investors.
Investors, operators and scientists who've built companies themselves. We work alongside founders from the first experiment to the next round, through the MSV Platform and our team in comms, creative, people and operations.
Team profiles
For founders
Building for the systems that matter? Pitch us.
We back founders turning breakthrough science into category-defining companies.
For investors
Invest with Main Sequence
Access Australia's deep tech frontier alongside us.
